Research Summary: Doxorubicin-loaded fucoidan capped gold nanoparticles for drugdelivery and photoacoustic imaging

August 17, 2016

The present study demonstrates the multifunctional doxorubicin-loaded fucoidan cappedgold nanoparticles (DOX-Fu AuNPs) for drug delivery and photoacoustic imaging (PAI). BiocompatibleAuNPs were synthesized using a naturally occurring fucoidan (Fu) as a capping and reducing agent.The Fu AuNPs synthesis was determined using UV–visible spectrum, and it was further characterizedusing high resolution transmission electron microscopy, energy dispersive X-ray spectroscopy, Fouriertransform infrared spectroscopy, and X-ray diffraction analysis. The release of DOX from DOX-Fu AuNPswas greater in acidic pH (4.5) than in neutral pH (7.4). The in vitro cytotoxic effect of fucoidan, Fu AuNPs,DOX, and DOX-Fu AuNPs inhibited the proliferation of human breast cancer cells with an inhibitoryconcentration of 35 g/mL, 30 g/mL, 15 g/mL, and 5 g/mL at 24 h. DOX-Fu AuNPs induced both earlyand late apoptosis in a concentration-dependent manner compared with untreated control cells. Theability of DOX-Fu AuNPs as a contrast agent for in vitro breast cancer imaging with PAI has been evaluated.These results suggest that the multifunctional DOX-Fu AuNPs for drug delivery and PAI can soon provideconsiderable contribution to human health.



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